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An interdisciplinary team from science, technology and dentistry – united by the vision of rethinking gum health.

Pierre Tangermann

CEO

Dr. Mirko Buchholz

CSO

Dr. Nadine Taudte

Lead Scientist

Dr. James Belcher

Dentist & Product Manager

Dr. Anett Theisen

Clinical Project Manager

Chris Land

Scientist

Wahhab Khan

Formulation Scientist

Jean-Marie Bryl

Communication Manager

Louis Buchholz

Head of Cuddles

Pierre Tangermann

CEO

Dr. Mirko Buchholz

CSO

Dr. Nadine Taudte

Lead Scientist

Dr. James Belcher

Dentist & Product Manager

Dr. Anett Theisen

Clinical Project Manager

Chris Land

Scientist

Wahhab Khan

Formulation Scientist

Jean-Marie Bryl

Communication Manager

Louis Buchholz

Head of Cuddles

Wissenschaftliche Publikationen zum

GingiTrap-Mikrobiom-Ansatz

Title: Effect of a bacterial glutaminyl cyclase inhibitor on multi-species biofilms.
Authors: Eick, Sigrun, Taudte, Nadine, Ramsbeck, Daniel, Magdoń, Anna, Sculean, Anton, Potempa, Jan, Buchholz, Mirko
Year of publication: 2025
Journal: Front. Oral Heal. 6, 1716625.
Link: DOI

Title: Novel small molecule targeting PgQC reduces Porphyromonas gingivalis virulence
Authors: Nadine Taudte, Linda Liebe, Nadine Jänckel, Daniel Ramsbeck, Stephan Schilling, Jan Potempa, Sigrun Eick, Mirko Buchholz
Year of publication: 2025
Journal: bioRxiv 2025.09.30.679452.
Link: DOI

Title: Tetrahydroimidazo[4,5-c]pyridine-Based Inhibitors of Porphyromonas gingivalis Glutaminyl Cyclase
Authors: Daniel Ramsbeck, Nadine Taudte, Nadine Jänckel, Stefanie Strich, Jens-Ulrich Rahfeld, Mirko Buchholz2
Year of publication: 2021
Journal: Pharmaceuticals 2021, 14(12). 1206.
Link: DOI

Title: Mammalian-like type II glutaminyl cyclases in Porphyromonas gingivalis and other oral pathogenic bacteria as targets for treatment of periodontitis
Authors:
Taudte, Nadine; Linnert, Miriam; Rahfeld, Jens‑Ulrich; Piechotta, Anke; Ramsbeck, Daniel; Buchholz, Mirko; Kolenko, Petr; Parthier, Christoph; Houston, John A.; Veillard, Florian; Eick, Sigrun; Potempa, Jan; Schilling, Stephan; Demuth, Hans‑Ulrich; Stubbs, Matthew T.
Year of publication: 2021
Journal: Journal of Biological Chemistry 296, 100263.
Link: DOI

Title: Effect of a bacterial glutaminyl cyclase inhibitor on multi-species biofilms.
Authors: Eick, Sigrun, Taudte, Nadine, Ramsbeck, Daniel, Magdoń, Anna, Sculean, Anton, Potempa, Jan, Buchholz, Mirko
Year of publication: 2025
Journal: Front. Oral Heal. 6, 1716625.
Link: DOI

Title: Novel small molecule targeting PgQC reduces Porphyromonas gingivalis virulence
Authors: Nadine Taudte, Linda Liebe, Nadine Jänckel, Daniel Ramsbeck, Stephan Schilling, Jan Potempa, Sigrun Eick, Mirko Buchholz
Year of publication: 2025
Journal: bioRxiv 2025.09.30.679452.
Link: DOI

Title: Tetrahydroimidazo[4,5-c]pyridine-Based Inhibitors of Porphyromonas gingivalis Glutaminyl Cyclase
Authors: Daniel Ramsbeck, Nadine Taudte, Nadine Jänckel, Stefanie Strich, Jens-Ulrich Rahfeld, Mirko Buchholz2
Year of publication: 2021
Journal: Pharmaceuticals 2021, 14(12). 1206.
Link: DOI

Title: Mammalian-like type II glutaminyl cyclases in Porphyromonas gingivalis and other oral pathogenic bacteria as targets for treatment of periodontitis
Authors:
Taudte, Nadine; Linnert, Miriam; Rahfeld, Jens‑Ulrich; Piechotta, Anke; Ramsbeck, Daniel; Buchholz, Mirko; Kolenko, Petr; Parthier, Christoph; Houston, John A.; Veillard, Florian; Eick, Sigrun; Potempa, Jan; Schilling, Stephan; Demuth, Hans‑Ulrich; Stubbs, Matthew T.
Year of publication: 2021
Journal: Journal of Biological Chemistry 296, 100263.
Link: DOI

Wissenschaftliche Publikationen zum

MinoPro-Minocyclin-Faden

Title: Extrudates of lipophilic tetracycline complexes: A new option for periodontitis therapy.
Authors: Kirchberg, M.; Eick, S.; Buchholz, M.; Kiesow, A;, Sarembe, S.; Mäder, K.
Year of publication: 2019
Journal: International Journal of Pharmaceuticals 572, 118794.
Link: DOI

Title: Controlled release minocycline-lipid-complex extrudates for the therapy of periodontitis with enhanced flexibility.
Authors: Kirchberg, M., Eick, S., Buchholz, M., Rosche, F., Kiesow, A., Sarembe, S., Mäder, K.
Year of publication: 2020
Journal: International Journal of Pharmaceuticals 586, 119578.
Link: DOI

Title: In Vitro Evaluation of Antimicrobial Activity of Minocycline Formulations for Topical Application in Periodontal Therapy.
Authors: Schmid, J.-L., Kirchberg, M., Sarembe, S., Kiesow, A., Sculean, A., Mäder, K., Buchholz, M., Eick, S..
Year of publication: 2020
Journal: Pharmaceutics 12, 352.
Link: DOI

Title: Preclinical Validation of MIN-T: A Novel Controlled-Released Formulation for the Adjunctive Local Application of Minocycline in Periodontitis.
Authors: Benedyk-Machaczka, M., Mydel, P., Mäder, K., Kaminska, M., Taudte, N., Naumann, M., Kleinschmidt, M., Sarembe, S., Kiesow, A., Eick, S., Buchholz, M.
Year of publication: 2024
Journal: Antibiotics 13, 1012.
Link: DOI

Title: Extrudates of lipophilic tetracycline complexes: A new option for periodontitis therapy.
Authors: Kirchberg, M.; Eick, S.; Buchholz, M.; Kiesow, A;, Sarembe, S.; Mäder, K.
Year of publication: 2019
Journal: International Journal of Pharmaceuticals 572, 118794.
Link: DOI

Title: Controlled release minocycline-lipid-complex extrudates for the therapy of periodontitis with enhanced flexibility.
Authors: Kirchberg, M., Eick, S., Buchholz, M., Rosche, F., Kiesow, A., Sarembe, S., Mäder, K.
Year of publication: 2020
Journal: International Journal of Pharmaceuticals 586, 119578.
Link: DOI

Title: In Vitro Evaluation of Antimicrobial Activity of Minocycline Formulations for Topical Application in Periodontal Therapy.
Authors: Schmid, J.-L., Kirchberg, M., Sarembe, S., Kiesow, A., Sculean, A., Mäder, K., Buchholz, M., Eick, S..
Year of publication: 2020
Journal: Pharmaceutics 12, 352.
Link: DOI

Title: Preclinical Validation of MIN-T: A Novel Controlled-Released Formulation for the Adjunctive Local Application of Minocycline in Periodontitis.
Authors: Benedyk-Machaczka, M., Mydel, P., Mäder, K., Kaminska, M., Taudte, N., Naumann, M., Kleinschmidt, M., Sarembe, S., Kiesow, A., Eick, S., Buchholz, M.
Year of publication: 2024
Journal: Antibiotics 13, 1012.
Link: DOI

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