PerioTrap Pharmaceuticals GmbH
Weinbergweg 22, 06120 Halle (Saale)
Dr. James Belcher, December 11, 2025
Periodontitis is a chronic inflammation of the tooth-supporting structures. It develops when bacteria accumulate in dental plaque and irritate the gums. If left untreated, the jawbone deteriorates, teeth loosen, and in the worst case, are lost. The main culprit is the bacterium Porphyromonas gingivalis, a so-called key pathogen that drives inflammation and alters the biofilm (the bacterial film on the teeth).
It sounds crazy, but it's scientifically proven: Periodontitis can intensify inflammation throughout the body. P. gingivalis produces enzymes (gingipains) that fuel immune responses. These pro-inflammatory substances travel through the bloodstream to other parts of the body – including the joints. Studies show that people with rheumatoid arthritis are more likely to have periodontitis, and untreated gum inflammation can even worsen rheumatoid arthritis symptoms.
Researchers discovered that P. gingivalis uses an enzyme that alters certain proteins in the body. This can "confuse" the immune system, causing the body to suddenly attack its own tissue (autoimmune reaction). The result: joint pain, swelling, and flare-ups of rheumatoid arthritis. PerioTrap® technology addresses this issue: it specifically blocks the virulence mechanisms (disease-causing properties) of P. gingivalis without interfering with its beneficial properties or other bacteria in the mouth.
Rheumatism patients have up to twice the risk of tooth loss if periodontitis remains untreated.
German Society for Periodontology (DG PARO); Arthritis Foundation – “Oral Health & Rheumatoid Arthritis”