What is P. gingivalis?

Porphyromonas gingivalis is an anaerobic bacterium that occurs naturally in the mouth. Although it is usually present only in small quantities, it can have a disproportionately large impact on the entire oral microbiome. Therefore, it is referred to as a "keystone pathogen"—a key organism that can disrupt the balance of the oral flora.

Why is this important?

P. gingivalis has unique mechanisms by which it influences the immune system and intensifies inflammation. This allows other harmful bacteria to survive and multiply more easily. The result: chronic inflammation, bleeding gums, tissue loss, and, in later stages, periodontitis.

What makes this bacterium particularly dangerous is its ability to systemically influence inflammation. It has been linked to cardiovascular disease, diabetes, and even Alzheimer's – an indication of how significantly the mouth affects overall health.

Science explained briefly

P. gingivalis produces so-called virulence factors such as gingipains. These enzymes help the bacterium to spread in tissue, evade immune responses, and make other germs more pathogenic. This creates an "inflammatory ecosystem" that permanently activates the immune system.

Modern research shows that it is not the quantity of the bacterium that is crucial, but its effect on the entire microbial community. This is precisely where PerioTrap® technology comes in: It selectively blocks the pathogenic mechanisms of P. gingivalis without destroying the entire microbiome.

What can you do?

• Brush your teeth thoroughly twice a day and clean the spaces between your teeth.
• Go for regular professional dental cleanings to reduce biofilm.
• Use microbiome-friendly products that promote a balanced oral flora.
• Reduce risk factors such as smoking, stress and a high-sugar diet.
• Act early if you notice signs such as bleeding gums or bad breath.

In summary

• P. gingivalis is a key pathogen that influences the balance of the microbiome.
• It can exacerbate inflammation and accelerate periodontitis.
• Targeted microbiome care offers better protection than aggressive, non-specific mouthwashes.
• A healthy oral flora protects not only the mouth, but the entire body.

Did you know?

Even small amounts of P. gingivalis can be enough to trigger dysbiosis, which leads to periodontitis – therefore, it is considered one of the most important pathogens in dentistry.

Sources

• Hajishengallis G. – Keystone pathogen theory and oral dysbiosis
• Lamont RJ – Mechanisms of Virulence of P. gingivalis
• Recent reviews on the role of P. gingivalis in systemic inflammation
• PerioTrap® Research Documentation on Selective Virulence Blockade